APPROPRIATE USE OF ORAL ANTIHYPERTENSIVE DRUGS EVALUATION IN NONDIALYSIS CHRONIC KIDNEY DISEASE PATIENT OF PRIVATE HOSPITAL IN EAST BEKASI 2018-2020

Authors

  • Sukma Widayani STIKes Mitra Keluarga
  • Wahyu Nuraini Hasmar STIKes Mitra Keluarga

DOI:

https://doi.org/10.47522/jmk.v1iIAHSC.123

Keywords:

Antihypertensive, Consecutive sampling, CKD, Evaluation, Hypertensive

Abstract

Introduction: Chronic Kidney Disease (CKD) is currently one of the most common diseases and being a concern in the world, including in Indonesia. The number of patients with CKD tends to increase year by year. Hypertension is a cause and effect of CKD and contributes to its development. This study aimed to evaluate the appropriateness use of oral antihypertensive drugs in patients with chronic kidney disease of private hospital in East Bekasi for the 2018-2020 period.

Method: The method used in this study was observational data taken retrospectively from the medical records of non- dialysis chronic kidney disease patients. The study population were all patients diagnosed with non-dialysis chronic kidney disease at the inpatient installation of private hospital in East Bekasi. The sample was taken by consecutive sampling method where the sample was determined based on the inclusion criteria of 50 patients.

Results: Evaluation of drug use in this study included right patient, right indication, right medication and right dose. The following results were obtained: right patient was 100%, right indication was 98%, right medication was 86% and right dose was 94.84%.

Conclusion It can be concluded that evaluation of oral antihypertensive drugs usage in patients with chronic kidney disease need to be done so that the contribution of hypertension to CKD development decreases.

Author Biographies

Sukma Widayani, STIKes Mitra Keluarga

Department of Pharmacy

Wahyu Nuraini Hasmar, STIKes Mitra Keluarga

Department of Pharmacy

References

Alaydrus, S., & Toding, N. (2019). Pola Penggunaan Obat Hipertensi Pada Pasien Geriatri Di Rumah Sakit Anutapura Palu Periode 08 Juli-08 Agustus 2019. Jurnal Mandala Pharmacon Indonesia, 5(02), 65–73. https://doi.org/10.35311/jmpi.v5i02.46

Anita, D. C. (2016). Status Nutrisi Pasien Gagal Ginjal Kronis Dengan Diabetes Mellitus Dan Non- Diabetes Mellitus. Media Ilmu Kesehatan, 5(2), 92–98. https://doi.org/10.30989/mik.v5i2.56

Anita, D. C. (2020). Penilaian Status Gizi Pasien Gagal Ginjal Kronis Melalui Biokimiawi Darah. Universitas ’Aisyiyah Yogyakarta.

Armstrong, C. (2014). JNC 8 guidelines for the management of hypertension in adults. American Family Physician, 90(7), 503–504.

Ashley, C. A. D. (2019). The Renal Drug Handbook: The Ultimate Prescribing Guide for Renal Practitioners, 4th edition. In European Journal of Hospital Pharmacy (Vol. 5). https://doi.org/10.1136/ejhpharm-2016-000883

Brunton, L. L. J. S. L. K. L. P. (2006). The Pharmacological Basis of Therapeutics. In McGraw-Hill (Vol.7). https://doi.org/10.1016/bs.seda.2018.06.002

Charles, Lacy F, Lora L. Armstrong, Morton P. Goldman, L. L. L. (2009). Drug Information Handbook: Vol. edisi 17. Lexi-comp.

Chobanian, A. V., Bakris, G. L., Black, H. R., Cushman, W. C., Green, L. A., Izzo, J. L., Jones, D. W., Materson, B. J., Oparil, S., Wright, J. T., & Roccella, E. J. (2003). Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension, 42(6), 1206–1252. https://doi.org/10.1161/01.HYP.0000107251.49515.c2 Dani, R., Utami, G. T., & Bayhakki. (2015). Hubungan Motivasi, Harapan, dan Dukungan Petugas

Kesehatan Terhadap Kepatuhan Pasien Gagal Ginjal Kronik Untuk Menjalani Hemodialisis. JOM, 2(2). https://doi.org/10.1007/s11139-020-00300-y

Depkes. (2017). InfoDATIN Pusat Data dan Informasi Kementerian Kesehatan RI: Situasi Penyakit Ginjal Kronis. 1–10. www.depkes.go.id/resources/download/pusdatin/infodatin/

Dipiro, J. T. (2005). Pharmacotherapy. In McGraw-Hill (Vol. 6). https://doi.org/10.1001/archinte.1980.00040020897004

Edmonston, D. L., & Sparks, M. A. (2020). Therapeutic options for chronic kidney disease-associated pulmonary hypertension. Current Opinion in Nephrology and Hypertension, 29(5), 497–507. https://doi.org/10.1097/MNH.0000000000000624

Erwinanto, Santoso, A., Putranto, J. N., Tedjasukmana, P., Suryawan, R., Rifqi, S., & Kasiman, S. (2015). Pedoman Tatalaksana Dislipidemia PERKI 2013. Indonesian Journal of Cardiology, 34(4), 245–270. https://doi.org/10.30701/ijc.v34i4.385

Fadhilah, A. Z. (2014). Chronic Kidney Disease Stage V. Definitions, 1(2), 110–113. https://doi.org/10.32388/yzopkc

Febriana, L. (2015). Hubungan Antara Kondisi Komorbid dan Mortalitas pada Pasien Gagal Ginjal Kronik yang Menjalani Hemodialisis di RSU Dokter Soedarso Pontianak. Universitas Tanjungpura. https://doi.org/10.1145/3132847.3132886

Garini, A. (2018). Kadar Hemoglobin Pada Pasien Gagal Ginjal Kronik Yang Menjalani Hemodialisis. JPP (Jurnal Kesehatan Poltekkes Palembang), 13(2), 111–116. https://doi.org/10.36086/jpp.v13i2.234

Guerrero-García, C., & Rubio-Guerra, A. F. (2018). Combination therapy in the treatment of hypertension. Drugs in Context, 7, 1–9. https://doi.org/10.7573/dic.212531 Guidelines. (2020). Hypertension – Diagnosis and Management.

Herzog, C. A., Asinger, R. W., Berger, A. K., Charytan, D. M., Díez, J., Hart, R. G., Eckardt, K. U.,

Kasiske, B. L., McCullough, P. A., Passman, R. S., Deloach, S. S., Pun, P. H., & Ritz, E. (2011). Cardiovascular disease in chronic kidney disease. A clinical update from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney International, 80(6), 572–586. https://doi.org/10.1038/ki.2011.223

Hill, Nathan R. Fatoba, Samuel T. Jennifer A. Hirst1, C., & A. O’Callaghan, Daniel S. Lasserson, F. D. R.H. (2009). Prevalence of chronic kidney disease: A systematic review and meta-analysis. Clinical Nephrology, 71(3), 244–254. https://doi.org/10.5414/CNP71244

Husna, N., & Larasati, N. (2019). Evaluasi Penggunaan Terapi Antihipertensi Pada Pasien Gagal Ginjal Kronik Dengan Hemodialisis. Media Ilmu Kesehatan, 8(1), 1–8. https://doi.org/10.30989/mik.v8i1.249

Hutagaol, E. V. (2017). Peningkatan Kualitas Hidup pada Penderita Gagal Ginjal Kronik yang Menjalani Terapi Hemodialisa Melalui Psychological Intervention di Unit Hemodialisa RS Royal Medan tahun 2016. Jurnal JUMANTIK, 2(1), 42–59. https://doi.org/10.1080/13507486.2015.1047603

IRR. (2014). Report Of Indonesia Renal Registry. Clinical Journal of the American Society of Nephrology, 1–36. https://doi.org/10.2215/CJN.02370316

IRR. (2017). 10 th Report Of Indonesian Renal Registry 2016. 1–46. IRR. (2018). 11th Report Of Indonesian Renal Registry 2018. Irr, 1–46. https://www.indonesianrenalregistry.org/data/IRR 2018.pdf JNC. (2014). JNC 8 Hypertension Guideline Algorithm. 311(5).

Kamaliah, N. I. Al, Cahaya, N., & Rahmah, S. (2021). Gambaran Karakteristik Pasien Gagal Ginjal Kronik Yang Menggunakan Suplemen Kalsium di Poliklinik Sub Spesialis Ginjal Hipertensi Rawat Jalan RSUD Ulin Banjarmasin. Jurnal Pharmascience, 8(1), 111. https://doi.org/10.20527/jps.v8i1.8599

Kandarini, Y. (2017). Tatalaksana Farmakologi Terapi Hipertensi. Divisi Ginjal Dan Hipertensi RSUP Sanglah Denpasar.

Kario, K., Tomitani, N., Kanegae, H., Ishii, H., Uchiyama, K., Yamagiwa, K., Shiraiwa, T., Katsuya, T., Yoshida, T., Kanda, K., Hasegawa, S., & Hoshide, S. (2017). Comparative effects of an Angiotensin II Receptor Blocker (ARB)/Diuretic vs. ARB/calcium-channel blocker combination on uncontrolled nocturnal hypertension evaluated by information and communication technology-based nocturnal home blood pressure monitorin. Circulation Journal, 81(7), 948–957. https://doi.org/10.1253/circj.CJ- 17-0109

Katzung, B. G., Masters, S. B., & Trevor, A. J. (2013). Farmakologi Dasar & Klinik Edisi 12. In Buku Kedokteran EGC, Jakarta. (12th ed., Issue 9). McGraw-Hill Medical.

KDIGO. (2013). Chapter 1: Definition and classification of CKD. Kidney International Supplements, 3(1), 19–62. https://doi.org/10.1038/kisup.2012.64

KDIGO. (2017). The interpretation of KDIGO 2017 clinical practice guideline update for the diagnosis, evaluation, prevention and treatment of chronic kidney disease-mineral and bone disorder (CKD- MBD). Chinese Journal of Evidence-Based Medicine, 17(8), 869–875. https://doi.org/10.7507/1672- 2531.201708015

KDIGO. (2021). KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease. Kidney International, 99(3), S1–S87. https://doi.org/10.1016/j.kint.2020.11.003

Kemenkes. (2016). Anatomi Fisiologi Manusia (A. S. Raimudus Chalik, Ida Malati Sadjati, Sunarti (ed.)). Pusdik SDM Kesehatan, Badan Pengembangan dan Pemberdayaan Sumber Daya Manusia Kesehatan. https://ejournal.poltektegal.ac.id/index.php/siklus/article/view/298%0Ahttp://repositorio.unan.edu.ni/2 986/1/5624.pdf%0Ahttp://dx.doi.org/10.1016/j.jana.2015.10.005%0Ahttp://www.biomedcentral.com/ 1471-2458/12/58%0Ahttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&P

Kementrian kesehatan RI. (2017a). Anatomi Fisiologi. Kementrian Kesehatan Republik Indonesia. Kementrian kesehatan RI. (2017b). Petunjuk Teknis Evaluasi Penggunaan Obat Di Fasilitas Kesehatan. Kementerian Kesehatan Republik Indonesia, 1–50.

Kepada, D., Ilmu, F., Universitas, K., & Mataram, M. (2019). Diajukan Kepada Fakultas Ilmu Kesehatan Universitas Muhammadiyah Mataram Sebagai Syarat Memperoleh Gelar Ahli Madya Farmasi”.

Kudo, D., Yoshida, Y., & Kushimoto, S. (2017). Permissive hypotension/hypotensive resuscitation and restricted/controlled resuscitation in patients with severe trauma. Journal of Intensive Care, 5(1), 1–8. https://doi.org/10.1186/s40560-016-0202-z

Lee, Y. Bin, Lee, J. S., Hong, S. hyeon, Kim, J. A., Roh, E., Yoo, H. J., Baik, S. H., & Choi, K. M. (2021).Optimal blood pressure for patients with chronic kidney disease: a nationwide population-based cohort study. Scientific Reports, 11(1), 1–8. https://doi.org/10.1038/s41598-021-81328-y

Levey, A. S., Schoolwerth, A. C., Burrows, N. R., Williams, D. E., Stith, K. R., & McClellan, W. (2009). Comprehensive Public Health Strategies for Preventing the Development, Progression, and Complications of CKD: Report of an Expert Panel Convened by the Centers for Disease Control and Prevention. American Journal of Kidney Diseases, 53(3), 522–535. https://doi.org/10.1053/j.ajkd.2008.11.019

Lloyd-Jones, D. M., Morris, P. B., Ballantyne, C. M., Birtcher, K. K., Daly, D. D., DePalma, S. M., Minissian, M. B., Orringer, C. E., & Smith, S. C. (2017). 2017 Focused Update of the 2016 ACC Expert Consensus Decision Pathway on the Role of Non-Statin Therapies for LDL-Cholesterol Lowering in the Management of Atherosclerotic Cardiovascular Disease Risk: A Report of the American College of Cardiology Task Fo. Journal of the American College of Cardiology, 70(14), 1785–1822. https://doi.org/10.1016/j.jacc.2017.07.745

Lubis, A. R., Tarigan, R. R., Nasution, B. R., Ramadani, S., & Vegas, A. (2016). Pedoman penatalaksanaan gagal ginjal kronik. Divisi Nefrologi- Hipertensi Departemen Ilmu Penyakit Dalam, 1–31.

Lukela, J. R., Harrison, R. V., Jimbo, M., Mahallati, A., Saran, R., & Annie, Z. (2019). Management of Chronic Kidney Disease Key points. UMHS Chronic Kidney Disease Guideline, July, 1–27.

Luyckx, V. A., Stanifer, J. W., & Tonelli, M. (2018). World Health Organization. Global Burden Of Kidney Disea. Bulletin of the World Health Organization, March, 414–422. https://www.who.int/bulletin/volumes/96/6/17-206441-ab/es/

Lydia, A., & Pringgodigdo, N. (2018). Kondisi kesehatan ginjal masyarakat Indonesia dan perkembangannya. Perhimpunan Nefrologi Indonesia, 1–25.

Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Böhm, M., Christiaens, T., Cifkova, R., De Backer, G., Dominiczak, A., Galderisi, M., Grobbee, D. E., Jaarsma, T., Kirchhof, P., Kjeldsen, S. E., Laurent, S., Manolis, A. J., Nilsson, P. M., Ruilope, L. M., … Wood, D. A. (2013). ESC Hypertension Guidelines for The Management of Arterial Hypertension. European Heart Journal,34(28), 2159–2219. https://doi.org/10.1093/eurheartj/eht151

Matzke, G. R., Aronoff, G. R., Atkinson, A. J., Bennett, W. M., Decker, B. S., Eckardt, K. U., Golper, T., Grabe, D. W., Kasiske, B., Keller, F., Kielstein, J. T., Mehta, R., Mueller, B. A., Pasko, D. A., Schaefer, F., Sica, D. A., Inker, L. A., Umans, J. G., & Murray, P. (2011). Drug dosing consideration in patients with acute and chronic kidney diseasea clinical update from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney International, 80(11), 1122–1137. https://doi.org/10.1038/ki.2011.322

McPhee, S. J., & Ganong, W. F. (2007). Fisiopatología médica: introducción a la medicina clínica (p.754).

Menkes, R. (2011). Modul penggunaan obat rasional. Kementerian Kesehatan RI, 1–192.

Muchtar, N. R., Tjitrosantoso, H., & Bodhi, W. (2015). Studi Penggunaan Obat Antihipertensi Pada Pasien Gagal Ginjal Kronik Yang Menjalani Perawatan Di Rsup Prof. Dr. R. D. Kandou Manado Periode Juli 2013 - Juni 2014. Jurnal Ilmiah Farmasi, 4(3), 22–28. https://doi.org/10.35799/pha.4.2015.8833

Muti, A. F., & Chasanah, U. (2016). Evaluasi Rasionalitas Penggunaan Diuretic pada Pasien Gagal Ginjal Kronik yang Dirawat Inap di RSUD Dr. Saiful Anwar Malang. Sainstech Farma, 9(2), 23–31.

Nathional Health Service. (2012). Enfermedad Renal Crónica en Inglaterra. 44. https://www.england.nhs.uk/improvement-hub/wp-content/uploads/sites/44/2017/11/Chronic-Kidney- Disease-in-England-The-Human-and-Financial-Cost.pdf

Ndraha, Suzanna. Jean Nadya PR, Marshell Tendean, M. S. (2018). Gambaran Penyakit Ginjal Kronik dan Komplikasinya di RSUD Koja Periode Juli-November 2017. 24(67), 1–4.

PERNEFRI. (2020). Integreted Collaboration for Excellent Kidney Care.

Pradningsih, A., Nopitasari, B. L., Nurbaety, B., & Zuhroh, H. (2020). Evaluasi Penggunaan Obat Antihipertensi pada Pasien Gagal Jantung Rawat Jalan di Rumah Sakit Umum Daerah Provinsi Nusa Tenggara Barat. Lumbung Farmasi: Jurnal Ilmu Kefarmasian, 1(2), 66. https://doi.org/10.31764/lf.v1i2.2542

Pranandari, R., & Supadmi, W. (2015). Faktor Risiko Gagal Ginjal Kronik di Unit Hemodialisis RSUD wates Kulon Progo. Majalah Farmaseutik, 11(2), 316–320. https://doi.org/10.1063/1.1655531

Prastiwi, A. D., & Wibowo, W. A. (2009). Efusi Pleura Eksudatif pada Pasien Gagal Ginjal Kronis yang Menjalani Hemodialisa Rutin. https://publikasiilmiah.ums.ac.id/xmlui/handle/11617/11239

Price, S. A., & Wilson, L. M. (2012). Patofisiologi Konsep Klinis Proses-Proses Penyakit (D. A. M. Huriawati Hartanto, Natalia Susi, Pita Wulansari (ed.); 6th ed.).

Pugh, D., Gallacher, P. J., & Dhaun, N. (2019). Management of Hypertension in Chronic Kidney Disease. Drugs, 79(4), 365–379. https://doi.org/10.1007/s40265-019-1064-1 RISKESDAS. (2013a). Penyajian Pokok-Pokok Hasil Riset Kesehatan Dasar 2013.

RISKESDAS. (2013b). Riset Kesehatan Dasar. In Trihono (Ed.), Badan Penelitian dan Pengembangan Kesehatan Kementrian Kesehatan RI. Menteri Kesehatan Republik Indonesia. https://doi.org/10.1517/13543784.7.5.803

Rivandi, J., & Yonata, A. (2015). Hubungan Diabetes Melitus Dengan Kejadian Gagal Ginjal Kronik. Jurnal Majority, 4(9), 27–34. http://juke.kedokteran.unila.ac.id/index.php/majority/article/view/1404/1246

Ruebner, R. L., & Pradhan, M. (2018). Chronic kidney disease. The 5-Minute Pediatric Consult, 8th Edition, May, 194–195.

Sa’idah, D., Sugihantoro, H., Hakim, A., & Maimunah, S. (2019). Evaluasi Rasionalitas Penggunaan Obat Antihipertensi di Instalasi Rawat Jalan RSUD dr. Soegiri Lamongan Periode Tahun 2017. Jurnal Ilmu Kefarmasian Indonesia, 17(1), 107. https://doi.org/10.35814/jifi.v17i1.650

Sagita, Tiffany Christine. Andreas Arie Setiawan, H. (2018). Hubungan Derajat Keparahan Gagal Ginjal Kronik Dengan Kejadian Penyakit Jantung Koroner. Diponegoro Medical Journal (Jurnal Kedokteran Diponegoro), 7(2), 472–484.

Salwa, A. (2013). Evaluasi Penggunaan Obat Antihipertensi pada Pasien Hipertensi dengan Gagal Ginjal di Instalasi Rawat Inap RS “X” tahun 2010. Fakultas Farmasi Universitas Muhammadiyah Surakarta.

Saran, R., Robinson, B., Abbott, K. C., Bragg-Gresham, J., Chen, X., Gipson, D., Gu, H., Hirth, R. A., Hutton, D., Jin, Y., Kapke, A., Kurtz, V., Li, Y., McCullough, K., Modi, Z., Morgenstern, H., Mukhopadhyay, P., Pearson, J., Pisoni, R., … Shahinian, V. (2020). US Renal Data System 2019 Annual Data Report: Epidemiology of Kidney Disease in the United States. American Journal of Kidney Diseases, 75(1), A6–A7. https://doi.org/10.1053/j.ajkd.2019.09.003

Sarwana, S. (2016). Hubungan penyakit ginjal kronik dengan anemia pada pasien rawat inap RSUD Bari Palembang tahun 2014. 52.

Sastroasmoro, S. (2011). Dasar-dasar metodologi penelitian klinis. Sagung seto.

Senduk, C. R., Palar, S., & Rotty, L. W. A. (2016). Hubungan anemia dengan kualitas hidup pasien penyakit ginjal kronik yang sedang menjalani hemodialisis reguler. E-CliniC, 4(1). https://doi.org/10.35790/ecl.4.1.2016.10941

Sinaga, C. R. H. T. F. (2017). Evaluasi Kerasionalan Penggunaan Antibiotik Pada Pasien Gagal Ginjal Di Rsup Prof. Dr. R. D. Kandou Manado. Pharmacon, 6(3), 10–19. https://doi.org/10.35799/pha.6.2017.16512

Sinha, A. D., & Agarwal, R. (2019). Clinical pharmacology of antihypertensive therapy for the treatment of hypertension in CKD. Clinical Journal of the American Society of Nephrology, 14(5), 757–764. https://doi.org/10.2215/CJN.04330418

Sirait, F. R. H. M. I. sari. (2017). Ensefalopati Uremikum pada Gagal Ginjal Kronis Uremic Encephalophaty in Chronic Kidney Disease. Jurnal Medula, 7, 19–24. http://repository.lppm.unila.ac.id/5039/1/J Medula UnilaVolume 7Nomor 1Januari 2017.pdf

Smith, D. K., Lennon, R. P., & Carlsgaard, P. B. (2020). Managing Hypertension Using Combination Therapy. American Family Physician, 101(6), 341–349.

Sukandar, E. Y. (2011). Iso Farmakoterapi. Ikatan Apoteker Indonesia.

Tamsil, Y., Moeis, E. S., & Wantania, F. (2020). Gambaran Anemia pada Subjek Penyakit Ginjal Kronik Stadium 4 dan 5 di Poliklinik Ginjal-Hipertensi RSUP Prof. Dr. R. D. Kandou. E-CliniC, 8(1), 60–66. https://doi.org/10.35790/ecl.8.1.2020.27097

Tandi, M., Mongan, A., & Manoppo, F. (2014). Hubungan Antara Derajat Penyakit Ginjal Kronik Dengan Nilai Agregasi Trombosit Di Rsup Prof. Dr. R. D. Kandou Manado. Jurnal E-Biomedik, 2(2). https://doi.org/10.35790/ebm.2.2.2014.5076

Tortora, G. J. (2011). Principles of Anatomi and Physiologi. Wiley. https://books.google.co.id/books?id=uNwfOPPYgKAC&printsec=frontcover#v=onepage&q&f=false

Triastuti, I. (2017). A cute kidney injury (AKI). Universitas Udayana. https://doi.org/10.1007/978-3-642- 54859-8_13

Tripathi, K. (2013). Medical Pharmacology seventh edition. In Bmj (7th ed., Vol. 2, Issue 5260). https://doi.org/10.1136/bmj.2.5260.1131

Tuloli, T. S., Madania, Adam, M. M., & Tuli, E. P. (2019). Evaluasi penggunaan obat pada pasien gagal ginjal kronik yang menjalani hemodialisis di Rsud Toto Kabila periode 2017-2018. Parapemikir: Jurnal Ilmiah Farmasi, 8(2), 25–32.

Unger, T., Borghi, C., Charchar, F., Khan, N. A., Poulter, N. R., Prabhakaran, D., Ramirez, A., Schlaich, M., Stergiou, G. S., Tomaszewski, M., Wainford, R. D., Williams, B., & Schutte, A. E. (2020). 2020 International Society of Hypertension Global Hypertension Practice Guidelines. Hypertension, 75(6), 1334–1357. https://doi.org/10.1161/HYPERTENSIONAHA.120.15026

Velasquez, M. T. (2015). Management of Hypertension in Chronic Kidney Disease. In Chronic Renal Disease. Elsevier Inc. https://doi.org/10.1016/B978-0-12-411602-3.00052-4

Weber, M. A., Schiffrin, E. L., White, W. B., Mann, S., Lindholm, L. H., Kenerson, J. G., Flack, J. M., Carter, B. L., Materson, B. J., Ram, C. V. S., Cohen, D. L., Cadet, J. C., Jean-Charles, R. R., Taler, S., Kountz, D., Townsend, R. R., Chalmers, J., Ramirez, A. J., Bakris, G. L., … Harrap, S. B. (2014). Clinical Practice Guidelines for the Management of Hypertension in the Community: A Statement by the American Society of Hypertension and the International Society of Hypertension Clinical Practice Guidelines for the Management of Hypertension in the Comm. Journal of Clinical Hypertension, 16(1), 14–26. https://doi.org/10.1111/jch.12237

Wells, Barbara G., DiPiro, J. T., Schwinghammer, T. L., & DiPiro, C. V. (2015). Pharmacotherapy Handbook (9th ed.). McGraw-Hill Education. https://doi.org/10.2514/6.2010-8193

Wells, Barbbara G., DiPiro, J. T., Schwinghammer, T. L., & DiPiro, C. V. (2009). PharmacotherapyHandbook. In The Annals of Pharmacotherapy (7th ed.). McGraw-Hill Companies, Inc. https://doi.org/10.1345/aph.10237

Wibawa, P. P. (2016). Ginjal dan urine. Diktat Biokimia, 1–33. https://simdos.unud.ac.id/uploads/file_pendidikan_1_dir/bbaf9351825f25035476868944b4f17f.pdf

Yusman, F. A., Dewi, R. T. K., Mashuri, Y. A., Nurhayatun, E., & Giani, M. T. (2020). Faktor yang Berkaitan dengan Kejadian Asites pada Pasien Penyakit Ginjal Kronik yang Menjalani Hemodialisis di RSUD Dr Moewardi Surakarta: Sebuah Studi Potong Lintang. Jurnal Penyakit Dalam Indonesia, 7(3), 154. https://doi.org/10.7454/jpdi.v7i3.420

Zhang, Q. L., & Rothenbacher, D. (2008). Prevalence of chronic kidney disease in population-based studies: Systematic review. BMC Public Health, 8. https://doi.org/10.1186/1471-2458-8-117

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2021-12-22